PANOP INJECTION
November 10, 2017ESOMED / NEXANE INJECTION
November 10, 2017
| METROMED 500 I.V. |
Metronidazole 500 mg/100 ml I. V. |
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| Composition : |
Each 100 ml of solution for infusion containing 500 mg of Metronidazole. |
| Indications : |
Metronidazole 500mg/100ml Intravenous Infusion is indicated in adults and children when oral medication is not possible for the following indications:
- The prophylaxis of postoperative infections due to sensitive anaerobic bacteria particularly species of Bacteroides and anaerobic Streptococci, during abdominal, gynaecological gastrointestinal or colorectal surgery which carries a high risk of occurrence of this type of infection. The solution may also be used in combination with an antibiotic active against aerobic bacteria.
- The treatment of severe intraabdominal and gynaecological infections in which sensitive anaerobic bacteria particularly Bacteriodes and anaerobic Streptococci have been identified or are suspected to be the cause.
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| Contraindications : |
Known hypersensitivity to Metronidazole or other imidazole derivatives or any of the excipients (see 6.1 List of excipients).
Metronidazole is contraindicated in the first trimester of pregnancy.
Use of Metronidazole is contraindicated in patients with end stage liver damage, haematopoietic disorders and uncontrolled diseases of the central or peripheral nervous system.
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| Adverse Effects : |
Nausea, vomiting, metallic taste, stomatitis and glossitis and dry mouth; myalgia; fever, skin rashes, urticaria, erythema multiforme anaphylactic shock, Quincke oedema, pustolosis, Stevens Johnson Syndrome and Toxic Epidermal Necrolysis. |
| Dosage : |
Prophylaxis against postoperative infections caused by anaerobic bacteria:
Adults: Intra-venous injection of single dose of 1000mg-1500mg, 30-60 minutes preoperatively or alternatively 500mg immediately before, during or after operation, then 500mg 8 hourly.
Children < 12 years: 20-30 mg/kg as a single dose given 1-2 hours before surgery.
Newborns with a gestation age <40 weeks: 10 mg/kg body weight as a single dose before operation.
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